张美萍

姓名:张美萍
性别:女
职称:教授(二级)/博士生导师
邮箱:meiping.zhang@jlau.edu.cn
个人基本情况:
国际动植物基因组大会系统基因组学分会主席,系统基因组学创始人之一,吉林农业大学植物学学科带头人。主要研究方向为植物系统基因组学与系统生物学,为该新兴学科的创建和发展做出了突出的贡献。提出并验证了DNA“拼图”结构学说 (DNA “Jigsaw Puzzle” Structure Model),对现代遗传变异理论做了重要补充;创建了全基因组水平高效、大规模克隆基因的新技术体系 (gExpress);创建了基因育种学;建立了大片段DNA重组理论和技术体系;揭示多倍体的起源与进化的分子机制;人参功能基因组学研究处于国际领先地位。
主持国家“863”项目1项,主持和参加省部级科研项目31项。主持和副主持美国农业部项目各1项,主持美国德州农业厅科研项目3项。共发表科学研究论文和报告169篇,其中在《Nucleic Acids Research》,《Nature Protocols》,《BMC Genomics》,《Scientific Reports》等世界著名科学期刊上发表论文65篇。参编美国著作1部,主编著作1部,副主编规划教材1部,参编规划教材1部。获国家发明专利12件。申请国际专利1项。在GenBank中注册248,993个人参Unigenes。获吉林省自然科学学术成果二等奖1项,三等奖1项。
教育背景
1983.9-1987.6,哈尔滨师范大学生物系,获学士学位。
1987.9-1990.6,哈尔滨师范大学生物系,获理学硕士学位。
1996.9-1999.6,吉林农业大学中药材学院学,获农学博士学位。
工作履历
1990.06-2000.12,吉林农业大学中药材学院,助教、讲师、副教授
2000.11-2003.11,东北农业大学,博士后
2001.01-现在,吉林农业大学生命科学学院,教授、博士生导师
2007.01-2016.12,美国Texas A&M University, 土壤与作物系, 国际合作研究,访问学者
学术(社会)兼职
任国际动植物基因组大会 Systems Genomics分会主席(2011-现在)。
中国农学会核农学会理事。
任BMC Genomics (2011至今),International Journal of Plant Genomics (2009至今), Journal of Plant Science and Molecular Breeding (2011至今), Genomics Discovery (2012至今) 和Agrotechnology (2013至今) 5个杂志的编委。
任Genome Biology (2010至今), BMC Genomics (2010至今), Molecular Genetics and Genomics (2010至今), Canadian Journal of Plant Science (2010至今), Plant Cell reports (2011至今), Plant Science (2011至今), PLoS ONE (2014至今), Pharmaceutical Biology (2015至今),Journal of Proteome Research (2016至今)9个科学期刊的特约评审。
任美国-以色列农业研发基金项目评审(2012-至今)。
主讲课程
硕士生:分子遗传学
博士生:系统基因组学
研究方向
系统基因组学和系统生物学
科研项目
1.反转座子调控人参皂苷合成的功能与机制研究,经费:12万元。时间:2024.1-2026.12。主持,在研。
2.高效鉴定人参三醇型皂苷生物合成相关基因并验证其关键基因功能的研究,经费:10万元。时间:2021.1-2023.12。主持,结题。
3.人参皂苷生物合成相关重要基因的挖掘及基因育种模式建立,吉林省发改委省级产业创新专项资金项目,经费:25万元。时间:2018.1-2019.12。主持,结题。
4.人参功能基因组学研究与应用,国家科技部重点科技研发计划,经费:240万元。时间:2013.1-2017.12。主持,结题。
5.吉林人参ESTs的建立及皂苷合成基因的克隆,吉林省科技厅国际合作项目,经费:15万元。时间:2008.1-2015.12。主持,结题。
6.人参基因育种技术的建立及优良农家品种选育,吉林省科技厅国际合作项目,经费:10万元。时间:2025.1-2027.12。参加,在研。
7.基于单细胞转录组测序解析茉莉酸甲酯调控人参不定根中皂苷生物合成积累的研究,吉林省科技厅自然基金面上项目,经费:10万元。时间:2025.1-2027.12。参加,在研。
8.miR156-SPL模块调控人参不定根生长分子机制的研究,吉林省教育厅科学技术项目,经费:5万元。时间:2025.1-2026.12。参加,在研。
9.人参TCP转录因子调控人参皂苷合成机制的研究,吉林省科技厅国际合作项目,经费:10万元。时间:2024.1-2026.12。参加,在研。
10.人参AP2/ERF转录因子基因的挖掘及功能验证,吉林省科技厅自然科学基金主题科学家专项,经费:15万元。时间:2019.1-2021.12。参加,结题。
11.人参单体皂苷Rg2生物合成途径重要基因的系统分析及功能鉴定,吉林省科技厅自然科学基金主题科学家专项,经费:15万元。时间:2018.1-2020.12。参加,结题。
12.基于全基因组水平上的吉林人参种质资源遗传多样性研究,吉林省科技厅国际合作项目,经费:20万元。时间:2018.1-2020.12。参加,结题。
13.人参皂苷生物合成相关CYP450基金家族的挖掘及功能验证,吉林省科技厅自然科学基金主题引导项目,经费:50万元。时间:2017.1-2019.12。参加,结题。
14.人参皂苷相关基因转化体规模化生产体系的建立,吉林省发改委省级产业创新专项资金项目,经费:50万元。时间:2016.1-2018.12。参加,结题。
15.吉林人参皂苷合成相关酶基因网络互作研究,吉林省科技厅国际合作项目,经费:10万元。时间:2010.1-2015.12。参加,结题。
科研奖励
1. 吉林人参基因家族的挖掘、鉴定及功能研究,吉林省科学技术奖自然科学三等奖,第五完成人,2025年。
2. 基因家族基因数量在同一物种中的遗传变异及其调控机制,吉林省自然科学学术成果奖二等奖,第一完成人,2012年。
学术论文及著作
- The bZIP transcription factor PgbZIP48-3 gene regulates ginsenoside biosynthesis in Panax ginseng. Horticulturae, 2026. (通讯作者)
- Transcriptome-wide identification and integrated analysis of age-related characteristic genes associated with age determination in forest-grown ginseng. Scientia Horticulturae, 2026. (通讯作者)
- Functional study of PgHDZ01 gene involved in the regulation of ginsenoside biosynthesis in Panax ginseng. Plants, 2025. (通讯作者)
- Transcriptome-wide identification and systematic analysis of the Retrotransposon genes and their roles in ginsenoside biosynthesis in Panax ginseng. BMC Plant Biology, 2025. (通讯作者)
- Potential participants and regulatory factors in ginsenoside biosynthesis of Panax ginseng C.A. Meyer: The role of endophytic fungus PBF-08. Plant Science, 2025. (通讯作者)
- Genome‑wide identification analysis of the ATP‑binding cassette transporter family and expression analysis under methyl jasmonate treatment in Panax ginseng. BMC Plant Biology, 2025. (通讯作者)
- Evolution, structural and functional characteristics of the MADS-box gene family and gene expression through methyl jasmonate regulation in Panax ginseng C.A. Meyer. Plants, 2024. (通讯作者)
- F Response of the ginseng C2H2-type zinc finger protein family PgZFPs gene to methyl jasmonate regulation. Phyton-International Journal of Experimental Botany, 2024. (通讯作者)
- A novel biosynthetic strategy for ginsenoside Ro: construction of a metabolically engineered Saccharomyces cerevisiae strain using a newly identified UGAT gene from Panax ginseng as the key enzyme gene and optimization of fermentation conditions. International Journal of Molecular Sciences, 2024. (通讯作者)
- Identification of PgRg1-3 gene for ginsenoside Rg1 biosynthesis as revealed by combining genome-wide association study and gene co-expression network analysis of Jilin ginseng core collection. Plants, 2024. (通讯作者)
- Functional validation of the cytochrome P450 family PgCYP309 gene in Panax ginseng. Biomolecules, 2024. (通讯作者)
- Genome-wide identification and integrated analysis of the FAR1/FHY3 gene family and genes expression analysis under methyl jasmonate treatment in Panax ginseng C. A. Mey. BMC Plant Biology, 2024. (通讯作者)
- Genome-wide identification and integrated analysis TCP genes controlling ginsenoside biosynthesis in Panax ginseng. BMC Plant Biology, 2024. (通讯作者)
- Genome-wide characterization, evolutionary analysis, and expression pattern analysis of the trihelix transcription factor family and gene expression analysis under MeJA treatment in Panax ginseng. BMC Plant Biology, 2023. (通讯作者)
- A portable nucleic acid sensor based on PCR for simple, rapid and sensitive testing of Botrytis cinerea in Ginseng. Plant Disease, 2023. (通讯作者)
- Transcriptome-wide integrated analysis of the PgGT25-04 gene in controlling ginsenoside biosynthesis in Panax ginseng. Plants, 2023. (通讯作者)
- The NAC transcription factor PgNAC41-2 gene involved in the regulation of ginsenoside biosynthesis in Panax ginseng. International Journal of Molecular Sciences, 2023. (通讯作者)
- Genetic and molecular dissection of ginseng Panax ginseng Mey. germplasm using highdensity genic SNP markers secondary metabolites and gene expressions. Frontiers in Plant Science, 2023. (通讯作者)
- Genome‑wide identification and systematic analysis of the HD‑Zip gene family and its roles in response to pH in Panax ginseng Meyer. BMC Plant Biology, 2023. (通讯作者)
- Transcriptome and phenotype integrated analysis identifies genes controlling ginsenoside Rb1 biosynthesis and reveals their interactions in the process in Panax ginseng. International Journal of Molecular Sciences, 2022. (通讯作者)
- Transcriptome analysis of MYB transcription factors family and PgMYB genes involved in salt stress resistance in Panax ginseng. BMC Plant Biology, 2022. (通讯作者)
- Transcriptome-wide characterization, evolutionary analysis, and expression pattern analysis of the NF-Y transcription factor gene family and salt stress response in Panax ginseng. BMC Plant Biology, 2022. (通讯作者)
- Characteristics of RNA alternative splicing and its potential roles in ginsenoside biosynthesis in a single plant of ginseng, Panax ginseng C.A. Meyer. Molecular Genetics and Genomics, 2021. (通讯作者)
- Integrative transcriptome analysis identifies new oxidosqualene cyclase genes involved in ginsenoside biosynthesis in Jilin ginseng. Genomics, 2021. (通讯作者)
- Basic leucine zipper (bZIP) transcription factor genes and their responses to drought stress in ginseng, Panax ginseng C.A. Meyer. BMC Genomics, 2021. (通讯作者)
- Analysis of the genes controlling three quantitative traits in three diverse plant species reveals the molecular basis of quantitative traits. Scientific Reports, 2020. (第一作者)
- Accurate prediction of maize grain yield using its contributing genes for gene-based breeding. Genomics, 2020. (第一作者)
- The bHLH gene family and its response to saline stress in Jilin ginseng, Panax ginseng C.A. Meyer. Molecular Genetics and Genomics, 2020. (通讯作者)
- Quantification of gene expression while taking into account RNA alternative splicing. Genomics, 2019. (第一作者)
- Transcriptome analysis identifies strong candidate genes for ginsenoside biosynthesis and reveals its underlying molecular mechanism in Panax ginseng C.A. Meyer. Scientific Reports, 2019. (通讯作者)
- Structural Variation, Functional Differentiation, and Activity Correlation of the Cytochrome P450 Gene Superfamily Revealed in Ginseng. Plant Genome, 2018. (通讯作者)
- Evolution, functional differentiation, and co-expression of the RLK gene family revealed in Jilin ginseng, Panax ginseng C.A. Meyer. Molecular Genetics and Genomics, 2018. (通讯作者)
- Functional differentiation and spatialtemporal co-expression networks of the NBS encoding gene family in Jilin ginseng, Panax ginseng C.A. Meyer. PLoS One, 2017. (通讯作者)
- The spatial and temporal transcriptomic landscapes of ginseng, Panax ginseng C. A. Meyer. Scientific Reports, 2015. (通讯作者)
- A plant-transformation-competent BIBAC library of ginseng (Panax ginseng C. A. Meyer) for functional genomics research and characterization of genes involved in ginsenoside biosynthesis. Molecular Breeding, 2012. (通讯作者)
专利
1. 王义,王爱民,陈靖雯,张美萍,王康宇,刘嘉庆,赵明珠,王艳芳,于靖辉。一种调控人参皂苷含量PgLBD45基因及其应用,发明专利,ZL202510866320.3,2026年。
2. 王义,于靖辉,张美萍,赵甜甜,王康宇,赵明珠。一种高产吡咯喹啉醌的人参内生菌及其应用,发明专利,ZL202411366776.5,2025年。
3. 张美萍,王义,王康宇,赵明珠,于笑晨。一种人参PgGUAT252645基因及其应用,发明专利,ZL202410199167.9,2025年。
4. 王康宇,王义,张美萍,赵明珠,姜杨,刘明明。一种人参PgMYC24基因及其应用,发明专利,ZL202310794775.X,2024年。
5. 王康宇,王义,张美萍,赵明珠,姜杨,刘明明。一种人参PgMYC24基因及其应用,发明专利,ZL202310794775.X,2024年。
6. 张美萍,王义,王康宇,赵明珠,李俐,于恩,刘涛。人参WRKY64-04基因及其应用,发明专利,ZL 202011157639.2,2023年。
7. 张美萍,王义,李俐,赵明珠,王康宇,孙春玉,姜悦,朱蕾。人参PgHDZ01基因及其在提高人参皂苷含量方面的应用,发明专利,ZL202010596923.3,2023年。